Neuromuscular Blocking Agents for Rapid Sequence Intubation - Summary Table

(April 29, 2023)

Abbreviations

Critical concerns about succinylcholine and hyperkalemia

Pathologic hyperkalemic response occurs by two distinct mechanisms: receptor upregulation and rhabdomyolysis. In either situation, potassium increase may approach 5 to 10 mEq per L within a few minutes and result in hyperkalemic dysrhythmias or cardiac arrest (3).

Succinylcholine absolute contraindications: situations that cause AChR upregulation (3):


Black Box Warning
The US-FDA issued a black box warning regarding pediatric patients.
Text transcript: (7)

“WARNING: VENTRICULAR DYSRHYTHMIAS, CARDIAC ARREST, AND DEATH FROM HYPERKALEMIC RHABDOMYOLYSIS IN PEDIATRIC PATIENTS.


Related drugs

References

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