Tetanus Immune Globulin
Emergency Medicine Executive Summary
Tetanus treatment: 500 units IM.
No adjustments needed.
Contraindications, Adverse effects, Warnings and Major Drug Interactions
Use with caution in individuals who have experienced allergic or other adverse effects secondary to other immunoglobulin-containing products.
Pregnancy and Lactation
Pregnancy Risk Factor Category C.
Animal reproduction and human pregnancy studies have not been conducted. The CDC recommends Tetanus Immune Globulin and tetanus toxoid-containing vaccine as part of the standard wound management to prevent tetanus in pregnant women.
Lactation: very low risk, safe. Minimal risk for breastfeeding and infant. The secretion of immunoglobulin into breast milk may help to transfer passive immunization to the child.
Half-life elimination: individuals with normal IgG concentration: ~23 days
Time to peak, plasma: IgG concentration: IM: ~2 days
Centers for Disease Control and Prevention (CDC), Epidemiology and Prevention of Vaccine-Preventable Diseases. Tejpratap S.P. Tiwari, MD; Pedro L. Moro, MD, MPH; and Anna M. Acosta, MD. Chapter 21: Tetanus. Updated December 2020.