- 40 mg lyophilized vial (IV)

- 10 mg, 20 mg and 40 mg standard and extended release capsules, tablets (PO)

Executive Summary

(July 5, 2023)

Omeprazole is the most prescribed proton pump inhibitor (PPI) worldwide. It reduces gastric acid secretion by irreversibly blocking the H+/K+ ATPase enzyme within the gastric parietal cells (9).

Adult dose for peptic ulcer bleeding

Intermittent dosing (3, 14)

Adult dose

Adult dose for peptic ulcer bleeding

Adult dose for stress peptic ulcer disease prophylaxis 


PPIs overview

Omeprazole and peptic ulcer bleeding

Appropriate dose and administration scheme of omeprazole for peptic ulcer bleeding (PUB)

PPIs and acute symptomatic management in the ED

Renal, hepatic and age adjustments


Excluding anaphylaxis and hypersensitivity reactions, omeprazole does not have any major short-term adverse effects or warnings for use in the acute setting or emergency department. 

Significant drug interactions
EMDrugs is currently reviewing drug interactions with omeprazole that are worth considering to prevent unexpected adverse events. 

Adverse effects associated with prolonged use of PPIs

EMDrugs is currently reviewing this topic to provide better understanding of the appropriateness of PPIs prescription in the ED.

Pregnancy and lactation

Pregnancy risk classification



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EMDrugs Team