Acute agitation associated with psychiatric disorders (2, 7):
Severe agitation (aggressive/threatening, non-cooperative):
IM: 0.1mg/kg, max 30mg/day for intramuscular administration.
1st versus 2nd generation antipsychotics for agitation
There are significant differences among first and second generation antipsychotics, and there is an abundant amount of literature available that compare olanzapine with haloperidol as well as other therapies to treat agitation. Clinically relevant data is summarized below:
Olanzapine is a second generation (atypical) antipsychotic. It has a wide range of different receptors activity: