Nitroglycerin

- 50 mg/250 ml of 5% dextrose solution, 200 μg/ml (IV).

- 50 mg/10 ml vials (IV).

- 0.4 mg tablets and spray (sublingual).

Executive Summary

(August 3, 2022)

Executive Summary

Nitroglycerin (NTG) is a nitrate prodrug of nitric oxide (NO), which primarily produces vasodilation as its main cardiovascular effect.

Adult dose for acute cardiogenic pulmonary edema (6, 14, 18, 20, 25)

Adult dose for angina and hypertension in acute coronary syndrome (11, 25)

5-10 μg/min infusion, titrate as needed (max 400 μg/min).

Adult dose

Adult dose for acute cardiogenic pulmonary edema (6, 14, 18, 20, 25)


Adult dose for angina and hypertension in acute coronary syndrome (11, 25)

Indications

Pharmacology of nitrates: nitroglycerin versus nitroprusside

Nitroprusside produces dose-related cyanide, which can be lethal.  A patient’s ability to buffer cyanide will be exceeded in less than one hour at the maximum dose rate (10 μg/kg/min); limit infusions at the maximum rate to as short a duration as possible.

Acute cardiogenic pulmonary edema and nitrates


Acute coronary syndrome and nitrates

Cautions 

For detailed content on adverse effects and warnings, please refer to the labeling information (13, 23, 24).




Pregnancy and lactation

Pregnancy risk classification


Lactation

References

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