- 30mg/ml vials, (IV, IM)

- 10mg and 30mg tablets (PO, sublingual)

- 0.5% drops (ophthalmic)

- 15.75mg/spray (intranasal)

Executive Summary

(March 2023)

Ketorolac is an NSAID with a potent analgesic effect that is very frequently indicated in the ED worldwide to treat moderate to severe acute pain. 

Adult dose for acute moderate to severe pain

Dosing considerations:

Adult dose

Adult dose for acute moderate to severe pain

Dosing considerations:


Ketorolac analgesic ceiling

Ketorolac vs opioids and opioid reduction requirements

NSAID Opioid reduction (%)

Ketorolac 9-66

Diclofenac 17-50

Ibuprofen 34-66

Ketoprofen 36-50

Meloxicam No benefit (1 study)


Pregnancy and lactation

Pregnancy risk classification


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