Calcium gluconate

1000 mg/10 ml ampoules (IV)

Executive Summary

(August 8, 2023)


Calcium gluconate is the calcium salt of gluconic acid. It is used intravenously to rapidly increase the blood calcium levels, as it plays a crucial role in various physiological processes such as heart function and nerve impulse conduction (15).


Adult dose for acute severe hypocalcemia (2, 11)

1-2 gr IV over 10 min, may be repeated every 10-60 min if necessary.


Adult dose for severe/emergent hyperkalemia (8, 9, 10)

1-2 gr IV over 2-5 min, may be repeated every 15-30 min if needed (persistent EKG signs of hyperkalemia, AV blockade, etc).


Adult dose in haemorrhagic shock / massive transfusion protocol (7)

3 gr IV every 4 units of citrated blood products.

Adult dose

Adult dose for acute severe hypocalcemia (2, 11)

1-2 gr IV over 10 min, may be repeated every 10-60 min if necessary.


Adult dose for severe/emergent hyperkalemia (8, 9, 10)

1-2 gr IV over 2-5 min, may be repeated every 15-30 min if needed (persistent EKG signs of hyperkalemia, AV blockade, etc).


Adult dose in haemorrhagic shock / massive transfusion protocol (7)

3 gr IV every 4 units of citrated blood products.

Indications


Calcium overview, calcium gluconate and calcium chloride

Overview


Calcium gluconate versus calcium chloride (6)

Hypocalcemia

Overview (4, 11)


Clinical manifestations of hypocalcemia (4, 11)


Relevance and management (4, 11)

Hyperkalemia, ECG changes, and the role of calcium

Overview and relevance


Clinical manifestations and ECG changes in hyperkalemia


Management

Calcium repletion in hemorrhagic shock

Cautions

Renal, hepatic and age adjustments

Pregnancy and lactation

Pregnancy risk classification


Lactation

References

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