ARTICLES in Emergency Medicine & Critical Care Pharmacotherapy

#Highlights

2023

Low-dose Ketamine vs Morphine for Acute Pain Management
December 2023

Abstract (Guo 2023)

Restrictive Fluid Therapy in Septic Shock

November 2023

Abstract (Jiang 2023)

Red Blood Cell Transfusion 2023 AABB Guidelines

October 2023

Abstract (Carson 2023)

Major Publications in the Critical Care Pharmacotherapy Literature: 2022

September 2023

Abstract (Gurnani 2023)

Comparison of acetaminophen, ketamine, or ketorolac versus morphine in the treatment of acute renal colic: A network meta-analysis. 

September 2023

Abstract (Alghamdi 2023)

2023 ESC Acute Coronary Syndromes Guidelines
August 2023

Preamble (Byrne 2023)

Recommended default antithrombotic therapy regimens in acute coronary syndrome patients without an indication for oral anticoagulation.

ACS, acute coronary syndrome; DAPT, dual antiplatelet therapy; HBR, high bleeding risk; NSTE-ACS, non-ST-elevation acute coronary syndrome; PCI, percutaneous coronary intervention; PPCI, primary percutaneous coronary intervention; UFH, unfractionated heparin. Algorithm for antithrombotic therapy in ACS patients without an indication for oral anticoagulation undergoing invasive evaluation. 

Vasopressin in septic shock, narrative review
July 2023

Abstract (Sacha 2023)

ARAMIS trial. Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke.
June 2023

Abstract (Chen 2023)

Tenecteplase Versus Alteplase for Acute Stroke: Mortality and Bleeding Complications
May 2023

Abstract (Murphy 2023)

Comparison of IV acetaminophen to IV or IM administered NSAIDs or opioids for patients presenting with moderate to severe acute pain conditions to the ED: systematic review and meta-analysis

Abstract (Qureshi 2023)

Etomidate as an induction agent for endotracheal intubation in critically ill patients

April 2023

Abstract (Kotani 2023)

Intravenous Magnesium As An Adjunct To Standard Of Care For Treatment Of Atrial Fibrillation 

April 2023

Comparing the Safety and Effectiveness of Ketamine Versus Benzodiazepine/Opioid Combination for Procedural Sedation in Emergency Medicine
March 2023

Abstract (Zaki 2023)

Adverse events reported in the current study included vomiting and nausea, visual hallucination, laryngospasm, apnea, and oxygen desaturation requiring intervention (Figure 6).

Hydrocortisone in Severe Community-Acquired Pneumonia

March 2023

Abstract (Dequin 2023)

European Stroke Organisation recommendation on tenecteplase for acute ischemic stroke

March 2023

Abstract (Alamowitch 2023)

Webinar presentation of ESO Expedited Recommendation on Tenecteplase for Acute Ischaemic Stroke by S. Alamowitch. 2023. 

Emergency Department management of patients with alcohol intoxication

March 2023

(Open access table)

Introduction (Strayer 2023)

High dose TXA for hemorrhage

March 2023

Abstract (Hmidan 2023)

Background
Standard dose (≤ 1 g) tranexamic acid (TXA) has established mortality benefit in trauma patients. The role of high dose IV TXA (≥2 g or ≥30 mg/kg as a single bolus) has been evaluated in the surgical setting, however, it has not been studied in trauma. We reviewed the available evidence of high dose IV TXA in any setting with the goal of informing its use in the adult trauma population.

Methods
We searched MEDLINE, EMBASE and unpublished sources from inception until July 27, 2022 for studies that compared standard dose with high dose IV TXA in adults (≥ 16 years of age) with hemorrhage. Screening and data abstraction was done independently and in duplicate. We pooled trial data using a random effects model and considered randomized controlled trials (RCTs) and observational cohort studies separately. We assessed the individual study risk of bias using the Cochrane Risk of Bias for RCTs and the Newcastle-Ottawa Scale for observational cohort studies. The overall certainty of evidence was assessed using the GRADE approach (Grading of Recommendations Assessment, Development and Evaluation).

Results
We included 20 studies with a combined total of 12,523 patients. Based on pooled RCT data, and as compared to standard dose TXA, high dose IV TXA probably decreases transfusion requirements (odds ratio [OR] 0.86, 95% confidence interval [CI] 0.76 to 0.97, moderate certainty) but with possibly no effect on blood loss (mean difference [MD] 43.31 ml less, 95% CI 135.53 to 48.90 ml less, low certainty), and an uncertain effect on thromboembolic events (OR 1.33, 95% CI 0.86 to 2.04, very low certainty) and mortality (OR 0.70, 95% CI 0.37 to 1.32, very low certainty).

Conclusion
When compared to standard dose, high dose IV TXA probably reduces transfusion requirements with an uncertain effect on thromboembolic events and mortality.

Level of evidence: Systematic review and meta-analysis, level IV.

Keywords: Hemorrhage; High dose; Mortality; Surgery; Thrombo-embolism; Tranexamic acid; Transfusion requirements; Trauma.

Pharmacotherapy in ventricular arrhythmias
March 2023

Abstract (Apte 2023)

Pharmacokinetic alterations in the critically ill
February 2023

Abstract (Morales 2023)

Acute management of migraine
January 2023

Abstract (Tzankova 2023)

Key Points:

Epinephrine in OHCA - Network Meta-Analysis, shockable and non-shockable rythms
January 2023

Abstract (Fernando 2023)

2022

IV Potassium and Magnesium in atrial fibrillation and atrial flutter in the ED

October 2022

Abstract (Cacioppo 2022)

IV MgSO4 for Acute Exacerbations of COPD Systematic Review

August 2022

Abstract (Aye 2022)

Antihistamines vs benzodiazepines for acute vertigo

July 2022

Pubmed

Abstract (Hunter 2022)

FAKT: Fentanyl vs placebo with ketamine and rocuronium for RSI in the ED
June 2022

Abstract (Ferguson 2022)

NORT-TEST 2 part A: Tenecteplase versus alteplase for the management of acute ischaemic stroke in Norway

June 2022

Abstract (Kvistad 2022)

Andexanet alfa vs four-factor prothrombin complex concentrate for the reversal of apixaban or rivaroxaban associated intracranial hemorrhage
June 2022

Abstract (Costa 2022)

PLUS: Balanced versus normal saline solutions in the critically ill
March 2022

Abstract (Finfer 2022)

Droperidol Emergency Medicine updates (narrative review)

March 2022

Abstract (Cisewski 2022)

2021

DOREMI: Milrinone vs Dobutamine in Cardiogenic Shock
August 2021

Abstract (Mathew 2021)

CDC Sexually Transmited Infections Treatment Guidelines
July 2021

Abstract (Workowski 2021)

These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11–14, 2019. The information in this report updates the 2015 guidelines. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease; 3) alternative treatment options for bacterial vaginosis; 4) management of Mycoplasma genitalium; 5) human papillomavirus vaccine recommendations and counseling messages; 6) expanded risk factors for syphilis testing among pregnant women; 7) one-time testing for hepatitis C infection; 8) evaluation of men who have sex with men after sexual assault; and 9) two-step testing for serologic diagnosis of genital herpes simplex virus. Physicians and other health care providers can use these guidelines to assist in prevention and treatment of STIs.

ACEP Task Force Report on Hyperactive Delirium with Severe Agitation

June 2021

Abstract (ACEP 2021)

NoPAC: TXA to reduce the need for nasal packing in epistaxis

June 2021

Abstract (Reuben 2021)

ED-AWARENESS Study: A Prospective, Observational Cohort Study of Awareness With Paralysis in Mechanically Ventilated Patients Admitted From the ED
May 2021

Abstract (Pappal 2021)

Effect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury
May 2021

Abstract (Roquilly 2021)

Ketamine for Acute Agitation in the ED

April 2021

Abstract (Lin 2021)

Conclusion

Risk of overcorrection in rapid intermittent bolus vs slow continuous infusion of hypertonic saline in symptomatic hyponatremia

January 2021

Abstract (Baek 2021)

2020

NEAR-Registry. Ketamine vs Etomidate and peri-intubation hypotension

November 2020

Abstract (NEAR Registry 2020)

IV alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis

November 2020

Abstract (Thomalla 2020)

HALT-IT: TXA in acute gastrointestinal bleeding

June 2020

Abstract (HALT-IT 2020)

Survival after IV vs IO Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest

 January 2020

Abstract (Daya 2020)

2019

CRASH-3. Tranexamic-acid in patients with traumatic brain injury
November 2019

Abstract (CRASH-3 2019)

ESETT: Three Anticonvulsants comparison for Status Epilepticus

November 2019

Abstract (Kapur 2019)

Conclusions

LEAP-2: Lefamulin vs Moxifloxacin for Community-Aquired Bacterial Pneumonia
November 2019

Abstract (Alexander 2019)

Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome. State of the art review.
May 2019

Abstract (Karslioglu 2019)

ROSE: Early neuromuscular blockade in ARDS
May 2019

Abstract (ROSE trial 2019)

Reversal of oral anticoagulation in intracerebral hemorrhage

February 2019

Abstract (Bower 2019)

Introduction: (references removed)

The NACSTOP Trial: A Multicenter, Cluster-Controlled Trial of Early Cessation of Acetylcysteine in Acetaminophen Overdose

February 2019

Abstract (Wong 2019)

2018

PARAMEDIC2: Epinephrine in OHCA

August 2018

NEJM (Open Access)

Abstract (Perkins 2018)

Meta-analysis: tenecteplase versus alteplase for acute ischemic stroke

August 2018

Springer (Open Access)

Abstract (Kheiri 2018)

EXTEND IA TNK: Tenecteplase 0.25mg/kg versus alteplase 0.9mg/kg before thrombectomy for AIS

April 2018

NEJM (Open Access)

Abstract (Campbell 2018)

SALT-ED: balanced crystalloids versus normal saline in the ED

March 2018

NEJM (Open Access)

Abstract (Self 2018)

2017

1. Minor head injury and vitamin K antagonists or direct oral (novel) anticoagulants
September 2017

Abstract (Riccardi 2017)